FISP® Cell-Free Sampling Probes
Sterile In-situ Sampling System for Fermentation and Cell Culture

Flownamics® Analytical Instruments has developed a sampling probe capable of withdrawing sterile, cell-free samples from fermentors and bioreactors. The FISP® probes not only allow off-line sampling, but also direct on-line sample transfer to biochemical or other types of analyzers. The FISP® sampling probe is a small tube-shaped sterilizable 316 stainless steel carrier surrounded by a tubular micro-porous membrane. The probes are available for 12, 19 and 25 mm ports, for laboratory, pilot or industrial scale vessels. FISP® is widely utilized in the fermentation and cell culture fields since it's introduction to the market in 1996.

Features of the FISP®

• Sterile, cell-free sampling for off-line and on-line analysis
• FISP® Probes can be autoclaved or sterilized in-place
• Used for aerobic or anaerobic bacterial cultures, as well as yeast, fungi, algae, insect, animal and mammalian cell cultures
• Risk free sampling due to elimination of bypass filters, which circulates material back into vessel
• Accommodates small laboratory vessels up to large full-scale production vessels with 12, 19 and 25 mm models
• Easy to use and maintain; no operator training required
• Interfaces the fermentor or bioreactor with a variety of analytical systems
• Biochemistry Analyzers
• Fraction collectors, Autosamplers
• Methanol analyzers
• Flow Injection Analysis (FIA)
• HPLC
• Biosensors
• Ion Chromatography
• Mass spec systems
• Design minimizes dead volume, which allows for consistent and accurate sampling, and reduces probe flush time
• Durable in design and construction to withstand the temperatures, pressures, viscosities, shear forces and chemicals typical of fermentation environments

Materials

• Probes and fittings are 316 stainless steel
• O-rings are Ethylene Propylene (EPDM)
• Membranes materials are Polypropylene & Ceramic